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The average fiber deviation and also the orientation degree of collagen fibers can be quantified based on the following equations: D(%) = 100 N DA i ⋅∑ and the OD(%) = 100 − D N i=1 90 Advances in Collagen/Hydroxyapatite Composite Materials 21 where, N is the number of fibers; DAi — correspond to deviation angle of each fiber; D (%) correspond to the average deviation of the fibers toward the applied electric field and OD(%) correspond to the orientation degree. Obviously the orientation is difficult to quantify and only a few methods permit this kind of measurements (and usually these are indirect methods); the orientation will be quantify based on the SEM images.

Dorozhkin, S. V. 2009. Calcium orthophosphate-based biocomposites and hybrid biomaterials. J Mater Sci 44:2343-2387. Ferreira, A. , Marquez, A. , Feijoo, J. L. and Lira-Olivares, J. 2008. Effect of type I collagen piezoelectricity on cellular adhesion. Iv Latin American Congress on Biomedical Engineering 2007, Bioengineering Solutions for Latin America Health, Vols 1 and 2 18(1,2):659-662. , Ficai, M. and Pall, S. 2009a. Colagen/Hydroxyapatite Interactions in Composite Biomaterials. Materiale Plastice 46(1):11-15.

Bonzani, I. , Gunatillake, P. and Stevens, M. M. 2007 Synthesis of two-component injectable polyurethanes for bone tissue engineering. Biomaterials 28(3):423-433. Chang, M. C. and Tanaka, J. 2002. FT-IR study for hydroxyapatite/collagen nanocomposite cross-linked by glutaraldehyde. Biomaterials 23:4811–4818. Clarke, I. , Green, D. , Delauney, C. and others. 2003. Current Status of Zirconia Used in Total Hip Implants. Journal of Bone and Joint Surgery 85(Supplement 4):7384. Advances in Collagen/Hydroxyapatite Composite Materials 29 Corces, A.

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